Chromosomal Instability Mechanisms

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About This MicroSim

Chapter 16: Cancer Genetics

Library: p5.js

Type: Interactive Diagram sim-id: chromosomal-instability
Library: p5.js
Status: Specified

Interactive visualization showing three mechanisms of chromosomal instability. Panel 1: Normal mitosis with proper spindle attachment and equal chromosome segregation. Panel 2: Mitotic checkpoint failure — chromosomes missegregate, producing one daughter cell with an extra chromosome (trisomy) and one missing a chromosome (monosomy). Panel 3: Centrosome amplification with multipolar spindle producing uneven distribution. Users can click buttons to toggle between mechanisms. Each mechanism shows before and after chromosome counts with a karyotype summary bar at the bottom.