Genetic Modifications for Xenotransplantation

Open Genetic Modifications for Xenotransplantation Fullscreen

About This MicroSim

Chapter 18: Frontier Topics and Emerging Technologies

Library: p5.js

Type: Interactive Diagram sim-id: xenotransplant-edits
Library: p5.js
Status: Specified

Interactive diagram showing a pig organ cell with three categories of genetic modifications needed for xenotransplantation. Category 1 (Knockout): Red X marks on pig genes encoding rejection-causing surface antigens (GGTA1, CMAH, B4GALNT2). Category 2 (Knock-in): Green plus marks for human immune regulatory genes added (CD46, CD55, thrombomodulin). Category 3 (Safety): Blue shield marks for inactivated porcine endogenous retroviruses. Users can click each modification category to expand a panel explaining why the modification is necessary and what happens without it. Include a "compatibility meter" that fills up as modifications are applied, illustrating how each edit reduces the risk of rejection.