Polygenic Risk Score Distribution

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About This MicroSim

Chapter 10: GWAS and Population Genetics

Library: Chart.js or p5.js

Type: Interactive visualization sim-id: prs-distribution
Library: Chart.js or p5.js
Status: Specified

Two overlapping bell curves representing the PRS distribution in cases (red) and controls (blue). The x-axis shows PRS value; the y-axis shows frequency. A vertical draggable threshold line allows the user to explore how different cutoffs change the proportion of cases vs. controls classified as "high risk." A readout panel shows sensitivity, specificity, and positive predictive value at the selected threshold. A slider controls the degree of separation between the two distributions (AUC from 0.55 to 0.85).