Linear Reference vs. Pangenome Graph

Open Linear Reference vs. Pangenome Graph Fullscreen

About This MicroSim

Chapter 18: Frontier Topics and Emerging Technologies

Library: p5.js

Type: Interactive Comparison sim-id: pangenome-graph-comparison
Library: p5.js
Status: Specified

Side-by-side interactive visualization. Left panel: Traditional linear reference genome shown as a single horizontal bar with a region highlighted where a structural variant exists — reads from individuals with the variant align poorly (shown with gaps and mismatches). Right panel: Pangenome graph shown as a network with branching paths at the variant site — reads from all individuals align cleanly to their respective paths. Users can toggle between individuals of different ancestries to see how their reads align to each reference type. Include a variant detection accuracy counter showing improved detection rates with the pangenome approach. Color code paths by population origin.