RNA Interference Pathway

Open RNA Interference Pathway Fullscreen

About This MicroSim

Chapter 12: Post-Transcriptional Regulation and Cell Identity

Library: p5.js

Type: Interactive animation sim-id: rnai-pathway
Library: p5.js
Status: Specified

An animated pathway diagram showing the parallel processing of miRNA and siRNA. The left side shows the miRNA pathway: pri-miRNA in the nucleus, Drosha cleavage, export by Exportin-5, Dicer processing, and RISC loading. The right side shows the siRNA pathway: long dsRNA, Dicer processing, and RISC loading. Both converge on RISC-mediated target recognition. A toggle switch allows the user to select "miRNA mode" (partial complementarity, translational repression shown as a stalled ribosome) or "siRNA mode" (perfect complementarity, mRNA cleavage shown as the mRNA breaking apart). Molecules are animated moving through each step when the user clicks "Play."