Two-Hit Hypothesis Comparison

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About This MicroSim

Chapter 16: Cancer Genetics

Library: p5.js

Type: Comparative Diagram sim-id: two-hit-hypothesis
Library: p5.js
Status: Specified

Side-by-side comparison of hereditary vs sporadic retinoblastoma. Left panel shows a germline mutation inherited at birth (first hit present in all cells) followed by a single somatic event (second hit) leading to tumor formation. Right panel shows two independent somatic mutations required in the same cell. Include a timeline showing age of onset for each pathway: hereditary (early childhood, bilateral) vs sporadic (later, unilateral). Use color coding: green for functional RB1 alleles, red for inactivated alleles.